Scientists announce a new technique for administering antibodies to patients. It’s about grafting an artificial crystal on antibodies. This will allow drugs or imaging agents to be delivered to the body.
This is a great advance for modern medicine. This new technique would to seek and treat accurately diseased cells. This will also limit side effects and increase the performance of treatments. The magazine Advanced Materials published the results of the study.
A new technological feat in favor of medicine
This technological achievement is due to the collaboration between TU Graz in Austria and the Australian Center for Blood Diseases at Monash University. It is the world’s first organometallic structure or MOF antibody and drug delivery system. Their result, more than convincing, would allow access to new forms of treatment for cardiovascular and autoimmune diseases or cancer.
“With over 80 different monoclonal antibodies approved for clinical use, this approach has enormous potential to improve these antibodies for the targeted delivery of diagnostic agents and therapeutic drugs. The goal is that ultimately, the clinical translation of this technology improves the quality of life of patients suffering from serious diseases”.
These crystals cling to diseased cells and deliver drugs to the area desired without impacting the rest of the body.
MOF antibody crystals have a metallo-organic structure, that is, they are made from metal ions of zinc, small organic molecules and carbonate. These are containers responsible for carrying specialized therapeutic products or fillers intended to help antibodies.
To revolutionize the way serious illnesses are treated
” The method offers the possibility of personalizing the treatment and, given the possible precision, can possibly modify the current dosage necessary for the patients, resulting in fewer side effects and making the treatments less expensive. »
The team called for investing in this project, because beyond the therapeutic potential, it turns out that this method will be cheaper and faster than traditional treatments.
We could treat cancer better
This technique could be the new approach commonly advocated for the treatment of cancer and serious diseases.
“With only 0.01% of chemotherapy currently reaching cancerous tissue, this revolutionary new method can increase the potency of drugs reaching their target. »
Dr Karen Alt, Head of the Nano Theranostics Laboratory at the Australian Center for Blood Diseases at Monash University