Une vieille personne atteinte de la maladie de Parkinson fait des exercices.

Soon a cure for Parkinson’s disease?

The Parkinson disease is an affection neurodegenerative incurable, best known for the hand tremors it causes. Currently there is no no treatment for the symptoms of this disease. Nevertheless, scientists have found a peptide capable of preventing the appearance of these. Concretely, researchers from the biology and biochemistry department ofUniversity of Bath worked on the molecule in question.

The aim of their research is tooptimize the interesting properties of the peptide. Ultimately, scientists hope develop a drug to treat Parkinson’s disease. In addition, the pathology is caused by an abnormality of the proteins, a cause similar to that ofAlzheimer’s and Type 2 diabetes.

So, work on this degenerative disease can help in understanding and processing of diseases with same type of anomaly.

Improper folding of proteins present in large numbers in the brain

The Parkinson disease is the result of a “Bad folding” of a particular human protein. Her name is alpha-synuclein (αS) and is abundant in human brains. When it folds up abnormally, it begins to agglomerate to form the Lewy body. Then the αS that form the many Lewy bodies become defective. In fact, they are mostly toxic to brain cells Who produce dopamine to ultimately lead to their death.

The symptoms of neurodegenerative disease occur due to the drop in dopamine secretion. In fact, the lack of this happiness hormone causes signals transmitted by the brain to the body get loud. Thus, the tremors observed in patients are the consequences of this failure.

Peptide has the potential to heal victims

In previous work, researchers from theUniversity of Bath have studied 209,952 peptides. Among them, the peptide 4554W turned out to be the most promising. Concretely, it can prevent the agglomeration of αS in Lewy bodies.

In their latest research, the same scientists modified the 4554W peptide to make it improve efficiency. They named the new version of the molecule 4654W (N6A). She presents two changes in the amino acid sequence parental.

In terms of results, it showed a superior efficiency to that of its predecessor. This superiority implies the reduction of bad folds, of the’aggregation of αS and their toxicity. However, researchers will not be able to develop an effective cure for Parkinson’s disease for several years.

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