Soon a nasal spray vaccine against Covid-19?

Ms Akiko Iwasakiresearcher at Howard Hughes Medical Institute at Yale University, has found a new vaccine strategy against the Coronavirus. The approach combines a prior mRNA Coronavirus vaccine injection with an rnasal spray appeal. Scientists called it “Prime and Spike”. In mice, the nasal cavity and lungs presented an army of immune defenders. Thus, the strategy protects a part of the body that is particularly vulnerable to infection: the nose.

Only the Coronavirus spike protein is included in the vaccine. The latter is part of a combination that is likely to protect people from infection. The strategy is based on the injection of a mRNA vaccine against virus which prepares the immune system to recognize SARS-CoV-2. Then the nasal spray strengthens the defenses at the level of the mucous membranes.

According to Ms. Iwasaki, such a strategy could counter the diminishing effectiveness of current mRNA vaccines against Covid-19.

Limit Covid-19 from gate guards

Shortly after the appearance of SARS-CoV-2 in Wuhan, China, the United States had found a ready-to-use mRNA vaccine. This technology, based on decades of research, has been shown to be safe and remarkably effective in preventing serious illness and death. But scientists now know that the effectiveness of these vaccines against the Coronavirus begins to decrease in the months following the second dose. Also, the increased protection conferred by a third dose may be temporary.

“It’s a smart strategy, and I hope they test it in humans. »

Louis, who did not take part in the work

Ms Iwasaki pointed to the inability of current mRNA vaccines to prevent infection. Although they are effective in preventing severe illness in most people, the virus can still spread.

Thus, instead of targeting the type of general immunity generated by mRNA vaccinesthe team focused on the moist, mucus-producing tissue that lines the nose and lungs. They aimed to strengthen the immune security at these virus entry sites. the nasal spray vaccine is given to people who already have immune memory cells through vaccines or infections. According to Iwasaki, these ” guards at the gatescould expel any potential viral invaders before they begin to multiply in the body. This would allow stop an individual’s infection and prevent the spread of the virus to other people.

What about strains of SARS-CoV-2?

the nasal spray vaccine the best known is FluMist . This flu vaccine relies on weakened viruses to generate immunity. However, FluMist is only approved for people between the ages of 2 and 49. The use of live viruses is not suitable for people with weakened immune systems.

On the other hand, the strategyPrime and Spikeallowed a protection of animals against the original strain of SARS-CoV-2, the cause of Covid-19. The team showed that around 80% of mice that received only an injected vaccine containing SARS-CoV-2 spike mRNA died within two weeks of exposure to the coronavirus. Conversely, all mice that were processed by the policy remained alive.

We hope that Prime and Spike can protect people against future variants of coronavirus.»



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